The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography.

Détails

ID Serval
serval:BIB_47951538A3DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography.
Périodique
Ciba Foundation Symposium
Auteur(s)
Friston K.J., Grasby P.M., Frith C.D., Bench C.J., Dolan R.J., Cowen P.J., Liddle P.F., Frackowiak R.S.
ISSN
0300-5208 (Print)
ISSN-L
0300-5208
Statut éditorial
Publié
Date de publication
1991
Volume
163
Pages
76-87; discussion 87-92
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The neuromodulatory effect of manipulating monoaminergic receptor function was assessed by combining a psychological and a pharmacological activation during repeated positron emission tomographic (PET) scans. The effects of buspirone (a 5-HT1A receptor partial agonist) on changes in regional cerebral blood flow (rCBF) associated with free word recall were examined. A factorial design was used to demonstrate a significant interaction (changes in rCBF brought about by psychological activation which depend on drug administration) in the left parahippocampal region. This interaction was an attenuation of increases in local neuronal activity (rCBF) related to memory function. Buspirone-induced decreases in rCBF, independent of the memory effect, were seen in the left prefrontal and parietal cortices. We suggest that combined psychological and pharmacological activation is a way of measuring direct (main) drug effects and modulatory effects on neurotransmission associated with cognitive functions (interaction).
Mots-clé
Adult, Brain Mapping/methods, Buspirone/pharmacology, Cerebrovascular Circulation/drug effects, Cognition/drug effects, Cognition/physiology, Humans, Male, Memory/drug effects, Neurosecretory Systems/drug effects, Neurotransmitter Agents/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
06/10/2011 20:27
Dernière modification de la notice
03/03/2018 16:50
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