Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Clinical implications of molecular neuropathology and biomarkers for malignant glioma.
Current Neurology and Neuroscience Reports
Publication types: Journal Article ; ReviewPublication Status: ppublish
Malignant gliomas are currently diagnosed based on morphological criteria and graded according to the World Health Organization classification of primary brain tumors. This algorithm of diagnosis and classification provides clinicians with an estimated prognosis of the natural course of the disease. It does not reflect the expected response to specific treatments beyond surgery (eg, radiotherapy or alkylating chemotherapy). Clinical experience has revealed that gliomas sharing similar histomorphological criteria might indeed have different clinical courses and exhibit highly heterogenous responses to treatments. This was very impressively demonstrated first for oligodendrogliomas. The presence or lack of combined deletions of the chromosomal segments 1p/19q was associated with different benefit from radiotherapy and chemotherapy. We review current molecular markers for malignant gliomas and discuss their current and future impact on clinical neuro-oncology.
Biological Markers, Brain Neoplasms/diagnosis, Brain Neoplasms/genetics, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 19, DNA Modification Methylases/genetics, DNA Repair Enzymes/genetics, Glioma/diagnosis, Glioma/genetics, Humans, Isocitrate Dehydrogenase/metabolism, Receptor, Epidermal Growth Factor/metabolism, Tumor Suppressor Proteins/genetics
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