Clinical implications of molecular neuropathology and biomarkers for malignant glioma.

Détails

ID Serval
serval:BIB_4794F1278098
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Clinical implications of molecular neuropathology and biomarkers for malignant glioma.
Périodique
Current Neurology and Neuroscience Reports
Auteur(s)
Tabatabai G., Hegi M., Stupp R., Weller M.
ISSN
1534-6293 (Electronic)
ISSN-L
1528-4042
Statut éditorial
Publié
Date de publication
2012
Volume
12
Numéro
3
Pages
302-307
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Malignant gliomas are currently diagnosed based on morphological criteria and graded according to the World Health Organization classification of primary brain tumors. This algorithm of diagnosis and classification provides clinicians with an estimated prognosis of the natural course of the disease. It does not reflect the expected response to specific treatments beyond surgery (eg, radiotherapy or alkylating chemotherapy). Clinical experience has revealed that gliomas sharing similar histomorphological criteria might indeed have different clinical courses and exhibit highly heterogenous responses to treatments. This was very impressively demonstrated first for oligodendrogliomas. The presence or lack of combined deletions of the chromosomal segments 1p/19q was associated with different benefit from radiotherapy and chemotherapy. We review current molecular markers for malignant gliomas and discuss their current and future impact on clinical neuro-oncology.
Mots-clé
Biological Markers, Brain Neoplasms/diagnosis, Brain Neoplasms/genetics, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 19, DNA Modification Methylases/genetics, DNA Repair Enzymes/genetics, Glioma/diagnosis, Glioma/genetics, Humans, Isocitrate Dehydrogenase/metabolism, Receptor, Epidermal Growth Factor/metabolism, Tumor Suppressor Proteins/genetics
Pubmed
Web of science
Création de la notice
28/05/2012 17:59
Dernière modification de la notice
03/03/2018 16:50
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