Clinical implications of molecular neuropathology and biomarkers for malignant glioma.

Details

Serval ID
serval:BIB_4794F1278098
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical implications of molecular neuropathology and biomarkers for malignant glioma.
Journal
Current Neurology and Neuroscience Reports
Author(s)
Tabatabai G., Hegi M., Stupp R., Weller M.
ISSN
1534-6293 (Electronic)
ISSN-L
1528-4042
Publication state
Published
Issued date
2012
Volume
12
Number
3
Pages
302-307
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Malignant gliomas are currently diagnosed based on morphological criteria and graded according to the World Health Organization classification of primary brain tumors. This algorithm of diagnosis and classification provides clinicians with an estimated prognosis of the natural course of the disease. It does not reflect the expected response to specific treatments beyond surgery (eg, radiotherapy or alkylating chemotherapy). Clinical experience has revealed that gliomas sharing similar histomorphological criteria might indeed have different clinical courses and exhibit highly heterogenous responses to treatments. This was very impressively demonstrated first for oligodendrogliomas. The presence or lack of combined deletions of the chromosomal segments 1p/19q was associated with different benefit from radiotherapy and chemotherapy. We review current molecular markers for malignant gliomas and discuss their current and future impact on clinical neuro-oncology.
Keywords
Biological Markers, Brain Neoplasms/diagnosis, Brain Neoplasms/genetics, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 19, DNA Modification Methylases/genetics, DNA Repair Enzymes/genetics, Glioma/diagnosis, Glioma/genetics, Humans, Isocitrate Dehydrogenase/metabolism, Receptor, Epidermal Growth Factor/metabolism, Tumor Suppressor Proteins/genetics
Pubmed
Web of science
Create date
28/05/2012 16:59
Last modification date
20/08/2019 13:53
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