Incrétines, sécrétion d'insuline et diabète

Détails

ID Serval
serval:BIB_478FD742F151
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Incrétines, sécrétion d'insuline et diabète
Périodique
Médecine sciences : M/S
Auteur(s)
Thorens B.
ISSN
0767-0974
Statut éditorial
Publié
Date de publication
09/2003
Peer-reviewed
Oui
Volume
19
Numéro
8-9
Pages
860-863
Langue
français
Résumé
Nutrient ingestion triggers a complex hormonal response aimed at stimulating glucose utilization in liver, muscle and adipose tissue to minimize the raise in blood glucose levels. Insulin secretion by pancreatic beta cells plays a major role in this response. Although the beta cell secretory response is mainly controlled by blood glucose levels, gut hormones secreted in response to food intake have an important role in potentiating glucose-stimulated insulin secretion. These gluco-incretin hormones are GLP-1 (glucagon-like peptide-1) and GIP (gluco-dependent insulinotropic polypeptide). Their action on pancreatic beta cells depends on binding to specific G-coupled receptors linked to activation of the adenylyl cyclase pathway. In addition to their effect on insulin secretion both hormones also stimulate insulin production at the transcriptional and translational level and positively regulate beta cell mass. Because the glucose-dependent insulinotropic action of GLP-1 is preserved in type 2 diabetic patients, this peptide is now developed as a novel therapeutic drug for this disease.
Mots-clé
Animals, Diabetes Mellitus, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Glucagon-Like Peptides, Humans, Insulin, Islets of Langerhans, Mice, Peptide Fragments, Protein Precursors, Rats
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:41
Dernière modification de la notice
08/05/2019 18:01
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