Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes.

Détails

ID Serval
serval:BIB_47850E8B7D5E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes.
Périodique
Digestive Diseases and Sciences
Auteur(s)
Brissot P., Farjanel J., Bourel D., Campion J.P., Guillouzo A., Rattner A., Deugnier Y., Desvergne B., Ferrand B., Simon M., Bourel M.
ISSN
0163-2116[print], 0163-2116[linking]
Statut éditorial
Publié
Date de publication
06/1987
Volume
32
Numéro
6
Pages
620-627
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Two baboons receiving intramuscular injections of ferric nitrilotriacetate over a two-year period were compared with two control baboons. The results indicate that in iron-overloaded animals: liver iron excess was major (maximal liver iron concentration values of 42 mumol/100 mg dry weight for both animals vs 1.3 +/- 0.2 (mean +/- SD) in controls) and chronic (for 15 months liver iron concentrations were higher than 15); iron deposition, although less abundant than in sinusoidal cells, was pronounced within parenchymal cells; serum transaminase activities were markedly increased; rare foci of perisinusoidal fibrosis were observed in areas of massive iron overload; and a dramatic decrease in hepatic 4-prolyl-hydroxylase activity was found, in contrast with unchanged glucosyltransferase and galactosyltransferase activities. In conclusion these findings suggest that, in our model, chronic liver iron overload: exerts a marked biochemical cytolytic effect; and does not produce significant hepatic fibrosis, possibly related to an inhibiting effect of ferric nitrilotriacetate complex on 4-prolyl-hydroxylase activity.
Mots-clé
Animals, Chronic Disease, Collagen/biosynthesis, Collagen/metabolism, Female, Ferric Compounds/adverse effects, Hemochromatosis/chemically induced, Hemochromatosis/enzymology, Iron/metabolism, Liver/enzymology, Liver/metabolism, Male, Nitrilotriacetic Acid/analogs & derivatives, Papio
Pubmed
Web of science
Création de la notice
24/01/2008 16:27
Dernière modification de la notice
03/03/2018 16:50
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