Article: article d'un périodique ou d'un magazine.
Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes.
Digestive Diseases and Sciences
Date de publication
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Two baboons receiving intramuscular injections of ferric nitrilotriacetate over a two-year period were compared with two control baboons. The results indicate that in iron-overloaded animals: liver iron excess was major (maximal liver iron concentration values of 42 mumol/100 mg dry weight for both animals vs 1.3 +/- 0.2 (mean +/- SD) in controls) and chronic (for 15 months liver iron concentrations were higher than 15); iron deposition, although less abundant than in sinusoidal cells, was pronounced within parenchymal cells; serum transaminase activities were markedly increased; rare foci of perisinusoidal fibrosis were observed in areas of massive iron overload; and a dramatic decrease in hepatic 4-prolyl-hydroxylase activity was found, in contrast with unchanged glucosyltransferase and galactosyltransferase activities. In conclusion these findings suggest that, in our model, chronic liver iron overload: exerts a marked biochemical cytolytic effect; and does not produce significant hepatic fibrosis, possibly related to an inhibiting effect of ferric nitrilotriacetate complex on 4-prolyl-hydroxylase activity.
Animals, Chronic Disease, Collagen/biosynthesis, Collagen/metabolism, Female, Ferric Compounds/adverse effects, Hemochromatosis/chemically induced, Hemochromatosis/enzymology, Iron/metabolism, Liver/enzymology, Liver/metabolism, Male, Nitrilotriacetic Acid/analogs & derivatives, Papio
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