Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.

Détails

ID Serval
serval:BIB_47586F9211AB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.
Périodique
Trends In Endocrinology and Metabolism
Auteur(s)
Bai P., Nagy L., Fodor T., Liaudet L., Pacher P.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
26
Numéro
2
Pages
75-83
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
; pdf : Review
Résumé
Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.
Pubmed
Web of science
Création de la notice
23/12/2014 14:00
Dernière modification de la notice
03/03/2018 16:49
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