Stimulating effect of thyroid hormones in peripheral nerve regeneration: research history and future direction toward clinical therapy.

Détails

Ressource 1Télécharger: NeuralRegenRes134599-9315863_023515.pdf (1130.51 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_47507594477A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Stimulating effect of thyroid hormones in peripheral nerve regeneration: research history and future direction toward clinical therapy.
Périodique
Neural Regeneration Research
Auteur(s)
Barakat-Walter I., Kraftsik R.
ISSN
1673-5374 (Print)
ISSN-L
1673-5374
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
4
Pages
599-608
Langue
anglais
Résumé
Injury to peripheral nerves is often observed in the clinic and severe injuries may cause loss of motor and sensory functions. Despite extensive investigation, testing various surgical repair techniques and neurotrophic molecules, at present, a satisfactory method to ensuring successful recovery does not exist. For successful molecular therapy in nerve regeneration, it is essential to improve the intrinsic ability of neurons to survive and to increase the speed of axonal outgrowth. Also to induce Schwann cell phenotypical changes to prepare the local environment favorable for axonal regeneration and myelination. Therefore, any molecule that regulates gene expression of both neurons and Schwann cells could play a crucial role in peripheral nerve regeneration. Clinical and experimental studies have reported that thyroid hormones are essential for the normal development and function of the nervous system, so they could be candidates for nervous system regeneration. This review provides an overview of studies devoted to testing the effect of thyroid hormones on peripheral nerve regeneration. Also it emphasizes the importance of combining biodegradable tubes with local administration of triiodothyronine for future clinical therapy of human severe injured nerves. We highlight that the local and single administration of triiodothyronine within biodegradable nerve guide improves significantly the regeneration of severed peripheral nerves, and accelerates functional recovering. This technique provides a serious step towards future clinical application of triiodothyronine in human severe injured nerves. The possible regulatory mechanism by which triiodothyronine stimulates peripheral nerve regeneration is a rapid action on both axotomized neurons and Schwann cells.
Mots-clé
axotomized neuron survival, biodegradable nerve growth guides, compound muscle action potential, microsurgery, peripheral nerve regeneration, reinnervation of denervated muscles, thyroid hormone nuclear receptors, thyroid hormones
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/05/2018 11:16
Dernière modification de la notice
08/05/2019 18:00
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