Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_474E8F7C5646
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Périodique
Revue Médicale Suisse
Auteur(s)
Bochud Murielle, Vollenweider Peter, Waeber Gérard
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2011
Volume
7
Numéro
315
Pages
2142, 2144-2142, 2145
Langue
français
Résumé
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
Mots-clé
Biological Markers/blood, Cardiovascular Diseases/blood, Cardiovascular Diseases/mortality, Cohort Studies, Glucose Transport Proteins, Facilitative/blood, Gout/blood, Gout/epidemiology, Humans, Hyperuricemia/blood, Hyperuricemia/epidemiology, Risk Factors, Switzerland/epidemiology, Uric Acid/blood
Pubmed
Création de la notice
07/11/2011 14:36
Dernière modification de la notice
03/03/2018 16:49
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