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Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Revue Médicale Suisse
2142, 2144-2142, 2145
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
Biological Markers/blood, Cardiovascular Diseases/blood, Cardiovascular Diseases/mortality, Cohort Studies, Glucose Transport Proteins, Facilitative/blood, Gout/blood, Gout/epidemiology, Humans, Hyperuricemia/blood, Hyperuricemia/epidemiology, Risk Factors, Switzerland/epidemiology, Uric Acid/blood
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