Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients.

Détails

ID Serval
serval:BIB_474831B6CFDD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients.
Périodique
Spinal Cord
Auteur(s)
Invernizzi M., Carda S., Rizzi M., Grana E., Squarzanti D.F., Cisari C., Molinari C., Renò F.
ISSN
1476-5624 (Electronic)
ISSN-L
1362-4393
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
53
Numéro
8
Pages
615-620
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
STUDY DESIGN: Case-control study.
OBJECTIVES: To assess serum myostatin levels, bone mineral density (BMD), appendicular skeletal muscle mass (ASMM) and serum sclerostin levels in chronic spinal cord injured (SCI) patients and healthy controls.
SETTING: SCI centre in Italy.
METHODS: Blood samples, whole-body bioelectrical impedance analysis and BMD measurement with the ultrasound technique at the calcaneus level were taken from patients suffering from chronic SCI (both motor complete and incomplete) and healthy control subjects.
RESULTS: A total of 28 SCI patients and 15 healthy controls were enrolled. Serum myostatin levels were statistically higher (P<0.01) in SCI patients compared with healthy controls. Similar results were found comparing both the motor complete and the motor incomplete SCI subgroups to healthy controls. Serum sclerostin was significantly higher in patients with SCI compared with healthy controls (P<0.01). BMD, stiffness and mean T-score values in SCI patients were significantly lower than those in healthy controls. Serum myostatin concentrations in the motor complete SCI subgroups correlated only with serum sclerostin levels (r(2)=0.42; P=0.001) and ASMM (r(2)=0.70; P=0.002) but not in healthy controls.
DISCUSSION: Serum myostatin and serum sclerostin are significantly higher in chronic SCI patients compared with healthy controls. They are potential biomarkers of muscle and bone modifications after SCI. This is the first study reporting an increase in serum myostatin in patients suffering from chronic SCI and a correlation with ASMM.
Mots-clé
Adolescent, Adult, Blood Chemical Analysis, Bone Morphogenetic Proteins/blood, Chronic Disease, Enzyme-Linked Immunosorbent Assay, Female, Genetic Markers, Humans, Male, Middle Aged, Movement Disorders/etiology, Myostatin/blood, Severity of Illness Index, Spinal Cord Injuries/blood, Spinal Cord Injuries/complications, Statistics as Topic, Statistics, Nonparametric, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/08/2015 18:32
Dernière modification de la notice
08/05/2019 18:00
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