What is the significance of leukoaraiosis in patients with acute ischemic stroke?

Détails

ID Serval
serval:BIB_473A56AEF75B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
What is the significance of leukoaraiosis in patients with acute ischemic stroke?
Périodique
Archives of Neurology
Auteur(s)
Wiszniewska  M., Devuyst  G., Bogousslavsky  J., Ghika  J., van Melle  G.
ISSN
0003-9942 (Print)
Statut éditorial
Publié
Date de publication
07/2000
Volume
57
Numéro
7
Pages
967-73
Notes
Journal Article --- Old month value: Jul
Résumé
BACKGROUND: Leukoaraiosis (LA) may have specific clinical correlates in patients with stroke, but this is not well investigated, so that the significance of LA in patients with stroke remains unclear. METHODS: In a study of 2289 patients with a first-ever acute ischemic stroke, LA was noted in 149 by the use of baseline computed tomography of the brain. These patients were compared with the non-LA group. Statistical tests, including Fisher exact test or a chi(2) test, were used to compare variables, and a multivariate approach using stepwise logistic regression was performed. RESULTS: Patients with LA were significantly older (73.7 vs 62.7 years; P<. 001), and had a higher incidence of hypertension (72.5% vs 47.1%; P<. 001) and subcortical or lacunar infarction (40.3% vs 25.4% and 21.5% vs 8.0%, respectively; P<.001) on neuroimaging studies, compared with the non-LA group. The most common cause of stroke in the LA group was presumed to be small-artery disease associated with hypertension (46% vs 13.5% in the non-LA group). Age and hypertension were very strongly associated with LA (respective odds ratios [95% confidence intervals], 1.06 [1.04-1.08] and 2.33 [1.60-3. 39]). In addition to these risk factors, a close relationship was found between LA and nonsevere stenosis (<50%) of the internal carotid artery (odds ratio, 2.23 [95% confidence interval, 1.32-3. 76]), although the significance of this association remains speculative. The outcome at 1 month after stroke was similar in both groups. CONCLUSION: Our results provide further evidence that LA is related primarily to small-vessel disease.
Mots-clé
Adolescent Adult Age Distribution Aged Ataxia/epidemiology Brain/blood supply/pathology Cardiovascular Diseases/epidemiology Carotid Artery, Internal/ultrasonography Carotid Stenosis/ultrasonography Cerebrovascular Accident/diagnosis/*epidemiology Comorbidity Female Humans Incidence Logistic Models Male Middle Aged Multivariate Analysis Neurodegenerative Diseases/diagnosis/*epidemiology Odds Ratio Paresis/epidemiology Prognosis Risk Factors Sex Distribution Vertebral Artery/ultrasonography
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 12:46
Dernière modification de la notice
08/05/2019 18:00
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