Clara cell protein and surfactant protein B in garbage collectors and in wastewater workers exposed to bioaerosols

Détails

ID Serval
serval:BIB_4732DA1DFF72
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clara cell protein and surfactant protein B in garbage collectors and in wastewater workers exposed to bioaerosols
Périodique
International Archives of Occupational and Environmental Health
Auteur(s)
Steiner Denise, Jeggli Stefan, Tschopp Alois, Bernard Alfred, Oppliger Anne, Hilfiker Sylvia, Hotz Philippe
ISSN
0340-0131
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
78
Numéro
3
Pages
189-197
Langue
anglais
Notes
SAPHIRID:49708
Résumé
OBJECTIVES: Inhalation of bioaerosols has been hypothesised to cause "toxic pneumonitis" that should increase lung epithelial permeability at the bronchioloalveolar level. Serum Clara cell protein (CC16) and serum surfactant protein B (SPB) have been proposed as sensitive markers of lung epithelial injury. This study was aimed at looking for increased lung epithelial permeability by determining CC16 and SPB in workers exposed to bioaerosols from wastewater or garbage. METHODS: Subjects (778 wastewater, garbage and control workers; participation 61%) underwent a medical examination, lung function tests [American Thoracic Society (ATS) criteria], and determination of CC16 and SPB. Symptoms of endotoxin exposure and several potential confounders (age, gender, smoking, kidney function, obesity) were looked for. Results were examined with multiple linear or logistic regression. RESULTS: Exposure to bioaerosols increased CC16 concentration in the wastewater workers. No effect of exposure on SPB was found. No clue to work-related respiratory diseases was found. CONCLUSIONS: The increase in CC16 in serum supports the hypothesis that bioaerosols cause subclinical "toxic pneumonitis", even at low exposure. [Authors]
Pubmed
Web of science
Création de la notice
12/05/2009 12:50
Dernière modification de la notice
03/03/2018 16:49
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