Coxiella burnetii as a possible cause of autoimmune liver disease: a case report.

Détails

Ressource 1Télécharger: BIB_4730CF019C31.P001.pdf (301.30 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_4730CF019C31
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Coxiella burnetii as a possible cause of autoimmune liver disease: a case report.
Périodique
Journal of Medical Case Reports
Auteur(s)
Kaech C., Pache I., Raoult D., Greub G.
ISSN
1752-1947[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
3
Pages
8870
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
INTRODUCTION: Q fever is a zoonotic infection that may cause severe hepatitis. Q-fever hepatitis has not yet been associated with autoimmune hepatitis and/or primary biliary cirrhosis. CASE PRESENTATION: We describe a 39-year-old man of Sri Lankan origin with chronic Q-fever hepatitis who developed autoantibodies compatible with autoimmune hepatitis/primary biliary cirrhosis overlap syndrome. Ursodeoxycholic acid in addition to antibiotic therapy markedly improved hepatic enzyme levels suggesting that autoimmunity, potentially triggered by the underlying infection, was involved in the pathogenesis of liver damage. CONCLUSION: We suggest that Coxiella burnetii might trigger autoimmune liver disease. Patients with Q-fever hepatitis who respond poorly to antibiotics should be investigated for serological evidence of autoimmune hepatitis, primary biliary cirrhosis or overlap syndrome, as these patients could benefit from adjunctive therapy with ursodeoxycholic acid. Conversely, C. burnetii serology might be necessary in patients with autoimmune liver disease in order to exclude underlying Coxiella infection.
Pubmed
Open Access
Oui
Création de la notice
29/01/2010 18:38
Dernière modification de la notice
08/05/2019 17:59
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