Role of platelets signaling in thrombus stalilization: potential therapeutic implications

Details

Serval ID
serval:BIB_47280F1D61B9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of platelets signaling in thrombus stalilization: potential therapeutic implications
Journal
Current Signal Transduction Therapy
Author(s)
Saller F., Schapira M., Angelillo-Scherrer A.
ISSN
1574-3624
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
3
Number
1
Pages
22-54
Language
english
Abstract
Platelets initiate arrest of bleeding at sites of vascular injury but also trigger inopportune arterial thrombosis, which causes heart attack and stroke. After formation of a single platelet monolayer at the site of injury, additional platelets are recruited into the growing hemostatic plug. Without further stabilization, the platelet plug disaggregates. Its stabilization is ensured by perpetuation of platelet activation. Drugs designed to prevent thrombus stabilization rather than inhibition of its formation, are currently not available. Platelet signaling of the perpetuation phase of platelet activation might represent a potential target for antiplatelet drugs that would prevent thrombosis without eliciting bleeding.
Keywords
Thrombus stabilization, Thrombosis, Antiplatelet drugs, Platelet signaling, Integrin signaling
Create date
04/02/2008 15:55
Last modification date
20/08/2019 13:53
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