Role of platelets signaling in thrombus stalilization: potential therapeutic implications

Détails

ID Serval
serval:BIB_47280F1D61B9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Role of platelets signaling in thrombus stalilization: potential therapeutic implications
Périodique
Current Signal Transduction Therapy
Auteur(s)
Saller F., Schapira M., Angelillo-Scherrer A.
ISSN
1574-3624
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
3
Numéro
1
Pages
22-54
Langue
anglais
Résumé
Platelets initiate arrest of bleeding at sites of vascular injury but also trigger inopportune arterial thrombosis, which causes heart attack and stroke. After formation of a single platelet monolayer at the site of injury, additional platelets are recruited into the growing hemostatic plug. Without further stabilization, the platelet plug disaggregates. Its stabilization is ensured by perpetuation of platelet activation. Drugs designed to prevent thrombus stabilization rather than inhibition of its formation, are currently not available. Platelet signaling of the perpetuation phase of platelet activation might represent a potential target for antiplatelet drugs that would prevent thrombosis without eliciting bleeding.
Mots-clé
Thrombus stabilization, Thrombosis, Antiplatelet drugs, Platelet signaling, Integrin signaling
Création de la notice
04/02/2008 16:55
Dernière modification de la notice
21/06/2018 11:47
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