Neuroimaging acute effects of cannabis smoking on skills related to driving with fMRI : results of a pilot study : V7

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_4711B8DB7D32
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Neuroimaging acute effects of cannabis smoking on skills related to driving with fMRI : results of a pilot study : V7
Titre de la conférence
16. GTFCh-Symposium Gesellschaft für Toxikologische und Forensische Chemie
Auteur(s)
Giroud Christian, Thomas Aurélien, Chtioui Haithem, Appenzeller Monique, Favrat Bernard, Buclin Thierry, Staub Christian, Mangin Patrice, Maeder Philippe, Fornari Eleonora
Adresse
Mosbach, Baden, 01.- 04. April 2009
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Editeur scientifique
Pragst F., Peters F.T.
Volume
76
Série
Toxichem + Krimtech
Pages
89
Langue
anglais
Notes
A pilot study was conducted on two occasional cannabis consumers, in order to investigate the effects of cannabis smoking on tracking capabilities. The subjects participated to a cross-over fMRI experiment based on a visuo-motor tracking task, once before and once after smoking, either cannabis or a placebo. We quantified the performance of the subjects by measuring the precision of the behavioral responses (i.e. percentage of time of correct tracking, reaction times to swerves) during the fMRI session. Interestingly, while the first subject had decreased performances after cannabis inhalation, the second subject performed the task with more accuracy after cannabis smoking. Maximum THC concentrations peaked at respectively 151 and 227 ng/ml whole blood. Blood THC values during fMRI, interpolated from concentrations determined before and after the experiment, were in the range of 12 to 8 ng/ml for the first subject and of 20 and 11 ng/ml for the second subject. The fMRI BOLD response revealed two effects of cannabis inhalation common to both subjects, namely a global decrease of activation of the visuo-motor areas, and the increase of activation of a fronto-parietal attentional network. Moreover, a supplementary activation in prefrontal and orbitofrontal areas was constantly found during tracking in the subject who performed more accurately after smoking; this activation was not present in the other subject with cannabis-related performance impairment. Taken together, these results suggest that the two subjects may follow different patterns of cerebral activation while performing the visuo-motor tracking task under the influence of cannabis. Recruitment of supplemental brain areas might compensate somehow the global decrease of brain activation after cannabis inhalation and partly mitigate harmful effects on tracking performances. These preliminary results need to be confirmed with more subjects.
Mots-clé
Cannabis, fMRI, driving simulation
Création de la notice
01/02/2010 13:02
Dernière modification de la notice
03/03/2018 16:49
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