Retinoic acid signaling affects cortical synchrony during sleep.

Détails

ID Serval
serval:BIB_46F4E5D8BDCC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Retinoic acid signaling affects cortical synchrony during sleep.
Périodique
Science
Auteur(s)
Maret S., Franken P., Dauvilliers Y., Ghyselinck N.B., Chambon P., Tafti M.
ISSN
1095-9203[electronic]
Statut éditorial
Publié
Date de publication
2005
Volume
310
Numéro
5745
Pages
111-113
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Delta oscillations, characteristic of the electroencephalogram (EEG) of slow wave sleep, estimate sleep depth and need and are thought to be closely linked to the recovery function of sleep. The cellular mechanisms underlying the generation of delta waves at the cortical and thalamic levels are well documented, but the molecular regulatory mechanisms remain elusive. Here we demonstrate in the mouse that the gene encoding the retinoic acid receptor beta determines the contribution of delta oscillations to the sleep EEG. Thus, retinoic acid signaling, which is involved in the patterning of the brain and dopaminergic pathways, regulates cortical synchrony in the adult.
Mots-clé
Animals, Cerebral Cortex/physiology, Delta Rhythm, Gene Deletion, Gene Expression, Mice, Mice, Inbred Strains, Polymorphism, Genetic, Promoter Regions, Genetic, Receptors, Retinoic Acid/biosynthesis, Receptors, Retinoic Acid/genetics, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Sleep/physiology, Transcription, Genetic, Tretinoin/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
03/03/2018 16:48
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