PD-1 (PDCD1) promoter methylation in Merkel cell carcinoma: prognostic relevance and relationship with clinico-pathological parameters.

Détails

ID Serval
serval:BIB_46EA15D53689
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
PD-1 (PDCD1) promoter methylation in Merkel cell carcinoma: prognostic relevance and relationship with clinico-pathological parameters.
Périodique
Modern pathology
Auteur(s)
Ricci C., Morandi L., Righi A., Gibertoni D., Maletta F., Ambrosi F., Agostinelli C., Uccella S., Asioli S., Sessa F., Pellilli M., Maragliano R., La Rosa S., Papotti M.G., Asioli S.
ISSN
1530-0285 (Electronic)
ISSN-L
0893-3952
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
32
Numéro
9
Pages
1359-1372
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Merkel cell carcinoma is an aggressive neuroendocrine skin tumor, for which several non-conclusive prognostic factors of adverse clinical behavior have been reported. As promoter methylation of the immune checkpoint receptor CD279/PD-1/PDCD1(mPDCD1) has been shown to be a prognostic factor in different cancers, we investigated its role in Merkel cell carcinoma. mPDCD1was assessed retrospectively in a cohort of 69 Merkel cell carcinoma patients from the University of Bologna, University of Turin and University of Insubria. Kaplan-Meier curves and log-rank tests were calculated for all variables. To assess the influence of mPDCD1, the Cox proportional hazards model and different Royston-Parmar models were evaluated. High PDCD1 methylation (mPDCD1 <sub>high</sub> ) was associated with a higher overall mortality at both the univariate analysis (log rank test: χ <sup>2</sup>  = 5.17, p = 0.023; permutation test: p = 0.023) and the multivariate analysis (HR = 2.111, p = 0.042). The other variables associated with a higher overall mortality at the multivariate analysis were clinical stage III-IV (HR = 2.357, p = 0.008), size > 2 cm (HR = 2.248, p = 0.031) and Merkel cell polyomavirus (HR = 0.397, p = 0.015). Further, mPDCD1 <sub>high</sub> was strongly associated with older age (81 vs 76 years, p = 0.042), absence of immune cells (92.6%, p < 0.001), no expression of PD-L1 by immune cells (70.4%, p = 0.041) and by both immune and tumor cells (70.4%, p = 0.001). mPDCD1 is a valid prognostic parameter in patients affected by Merkel cell carcinoma. In addition, it could provide an estimate of the global PD-1/PD-L1 expression with potentially relevant implications from a therapeutic point of view.
Pubmed
Web of science
Création de la notice
16/04/2019 7:38
Dernière modification de la notice
01/10/2019 5:09
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