The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.

Détails

ID Serval
serval:BIB_46C8C7D5FAEF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.
Périodique
Cell
Auteur(s)
Wilson A.C., LaMarco K., Peterson M.G., Herr W.
ISSN
0092-8674[print], 0092-8674[linking]
Statut éditorial
Publié
Date de publication
07/1993
Volume
74
Numéro
1
Pages
115-125
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Upon lytic infection of permissive cells, the herpes simplex virus (HSV) transactivator protein VP16 associates with an accessory protein termed host cell factor (HCF). Binding to HCF activates VP16 for association with the octamer motif-binding protein Oct-1, to form a multiprotein-DNA complex responsible for activating transcription of the HSV immediate early genes. We show that HCF comprises a series of related polypeptides that range from 110 to 300 kd, all of which are encoded by a single gene. Although there is no obvious sequence similarity between HCF and other known proteins, HCF contains eight repeats of a new 26 amino acid motif. cDNAs encoding HCF predict a large open reading frame of 2035 codons. When expressed in human cells, this large open reading frame encodes both the 300 kd and smaller HCF polypeptides, indicating that the smaller polypeptides arise by processing of the 300 kd protein.
Mots-clé
Amino Acid Sequence, DNA-Binding Proteins/metabolism, Herpes Simplex Virus Protein Vmw65/genetics, Herpes Simplex Virus Protein Vmw65/metabolism, Host Cell Factor C1, Humans, Molecular Sequence Data, Octamer Transcription Factor-1, Open Reading Frames, Protein Binding, Protein Precursors/metabolism, Protein Processing, Post-Translational, Repetitive Sequences, Nucleic Acid, Simplexvirus, Transcription Factors/genetics, Transcription Factors/metabolism, Transcription, Genetic
Pubmed
Web of science
Création de la notice
24/01/2008 16:36
Dernière modification de la notice
03/03/2018 16:48
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