Identification of structural variation in mouse genomes.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_46C695F7B599
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Identification of structural variation in mouse genomes.
Périodique
Frontiers in Genetics
Auteur(s)
Keane T.M., Wong K., Adams D.J., Flint J., Reymond A., Yalcin B.
ISSN
1664-8021 (Electronic)
ISSN-L
1664-8021
Statut éditorial
Publié
Date de publication
2014
Volume
5
Pages
192
Langue
anglais
Résumé
Structural variation is variation in structure of DNA regions affecting DNA sequence length and/or orientation. It generally includes deletions, insertions, copy-number gains, inversions, and transposable elements. Traditionally, the identification of structural variation in genomes has been challenging. However, with the recent advances in high-throughput DNA sequencing and paired-end mapping (PEM) methods, the ability to identify structural variation and their respective association to human diseases has improved considerably. In this review, we describe our current knowledge of structural variation in the mouse, one of the prime model systems for studying human diseases and mammalian biology. We further present the evolutionary implications of structural variation on transposable elements. We conclude with future directions on the study of structural variation in mouse genomes that will increase our understanding of molecular architecture and functional consequences of structural variation.
Mots-clé
Heterogeneous Stock (HS), Sanger Mouse Genomes Project, array comparative genome hybridization (aCGH), inbred strains of mice, next-generation sequencing (NGS), paired-end mapping (PEM), structural variation (SV)
Pubmed
Open Access
Oui
Création de la notice
18/12/2014 18:38
Dernière modification de la notice
08/05/2019 17:58
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