Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.

Détails

ID Serval
serval:BIB_469E353C2B8F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Hosoda C., Hiroyama M., Sanbe A., Birumachi J., Kitamura T., Cotecchia S., Simpson P.C., Tsujimoto G., Tanoue A.
ISSN
0363-6135 (Print)
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
293
Numéro
1
Pages
H514-H519
Langue
anglais
Résumé
Attenuation of early restenosis after percutaneous coronary intervention (PCI) is important for the successful treatment of coronary artery disease. Some clinical studies have shown that hypertension is a risk factor for early restenosis after PCI. These findings suggest that alpha(1)-adrenergic receptors (alpha(1)-ARs) may facilitate restenosis after PCI because of alpha(1)-AR's remarkable contribution to the onset of hypertension. In this study, we examined the neointimal formation after vascular injury in the femoral artery of alpha(1A)-knockout (alpha(1A)-KO), alpha(1B)-KO, alpha(1D)-KO, alpha(1A)-/alpha(1B)-AR double-KO (alpha(1AB)-KO), and wild-type mice to investigate the functional role of each alpha(1)-AR subtype in neointimal formation, which is known to promote restenosis. Neointimal formation 4 wk after wire injury was significantly (P < 0.05) smaller in alpha(1AB)-KO mice than in any other group of mice, while blood pressures were not altered in any of the groups of mice after wire injury compared with those before it. These results suggest that lack of both alpha(1A)- and alpha(1B)-ARs could be necessary to inhibit neointimal formation in the mouse femoral artery.
Mots-clé
Adrenergic alpha-1 Receptor Antagonists, Animals, Femoral Artery/injuries, Femoral Artery/metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Adrenergic, alpha-1/metabolism, Signal Transduction, Tunica Intima/metabolism, Tunica Intima/pathology
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 13:52
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