NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.

Détails

ID Serval
serval:BIB_469324CB9554
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.
Périodique
Journal of Biological Chemistry
Auteur(s)
Cui X.Y., Hu Q.D., Tekaya M., Shimoda Y., Ang B.T., Nie D.Y., Sun L., Hu W.P., Karsak M., Duka T., Takeda Y., Ou L.Y., Dawe G.S., Yu F.G., Ahmed S., Jin L.H., Schachner M., Watanabe K., Arsenijevic Y., Xiao Z.C.
ISSN
0021-9258
Statut éditorial
Publié
Date de publication
06/2004
Peer-reviewed
Oui
Volume
279
Numéro
24
Pages
25858-25865
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/contactin is a functional ligand of Notch during oligodendrocyte maturation, revealing the existence of another group of Notch ligands. Here, we establish that NB-3, a member of the F3/contactin family, acts as a novel Notch ligand to participate in oligodendrocyte generation. NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Thus, the NB-3/Notch signaling pathway may prove to be a molecular handle to treat demyelinating diseases.
Mots-clé
Active Transport, Cell Nucleus, Animals, Carrier Proteins/physiology, Cell Adhesion Molecules, Neuronal/physiology, Cell Differentiation, Cells, Cultured, Mice, Mice, Inbred BALB C, Neurons/cytology, Oligodendroglia/cytology, Rats, Rats, Wistar, Receptor, Notch1, Receptors, Cell Surface/physiology, Signal Transduction, Stem Cells/cytology, Transcription Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 13:31
Dernière modification de la notice
08/05/2019 17:57
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