Metabolism and proliferation share common regulatory pathways in cancer cells.

Détails

ID Serval
serval:BIB_4687DB122CA9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Metabolism and proliferation share common regulatory pathways in cancer cells.
Périodique
Oncogene
Auteur(s)
Fritz V., Fajas L.
ISSN
1476-5594 (Electronic)
ISSN-L
0950-9232
Statut éditorial
Publié
Date de publication
2010
Volume
29
Numéro
31
Pages
4369-4377
Langue
anglais
Résumé
Cancer development involves major alterations in cells' metabolism. Enhanced glycolysis and de novo fatty acids synthesis are indeed characteristic features of cancer. Cell proliferation and metabolism are tightly linked cellular processes. Others and we have previously shown a close relationship between metabolic responses and proliferative stimuli. In addition to trigger proliferative and survival signaling pathways, most oncoproteins also trigger metabolic changes to transform the cell. We present herein the view that participation of cell-cycle regulators and oncogenic proteins to cancer development extend beyond the control of cell proliferation, and discuss how these new functions may be implicated in metabolic alterations concomitant to the pathogenesis of human cancers.
Mots-clé
Animals, Cell Cycle/physiology, Cell Proliferation, Humans, Lipid Metabolism/physiology, Models, Biological, Neoplasms/metabolism, Neoplasms/pathology, Signal Transduction/genetics, Signal Transduction/physiology, Transcription Factors/metabolism, Transcription Factors/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/03/2013 16:55
Dernière modification de la notice
08/05/2019 17:57
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