High-dimensional Multivariate Mediation with Application to Neuroimaging Data.
Details
Serval ID
serval:BIB_4675681D2485
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High-dimensional Multivariate Mediation with Application to Neuroimaging Data.
Journal
Biostatistics
ISSN
1468-4357 (Electronic)
ISSN-L
1465-4644
Publication state
Published
Issued date
01/04/2018
Peer-reviewed
Oui
Volume
19
Number
2
Pages
121-136
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
Mediation analysis is an important tool in the behavioral sciences for investigating the role of intermediate variables that lie in the path between a treatment and an outcome variable. The influence of the intermediate variable on the outcome is often explored using a linear structural equation model (LSEM), with model coefficients interpreted as possible effects. While there has been significant research on the topic, little work has been done when the intermediate variable (mediator) is a high-dimensional vector. In this work, we introduce a novel method for identifying potential mediators in this setting called the directions of mediation (DMs). DMs linearly combine potential mediators into a smaller number of orthogonal components, with components ranked based on the proportion of the LSEM likelihood each accounts for. This method is well suited for cases when many potential mediators are measured. Examples of high-dimensional potential mediators are brain images composed of hundreds of thousands of voxels, genetic variation measured at millions of single nucleotide polymorphisms (SNPs), or vectors of thousands of variables in large-scale epidemiological studies. We demonstrate the method using a functional magnetic resonance imaging study of thermal pain where we are interested in determining which brain locations mediate the relationship between the application of a thermal stimulus and self-reported pain.
Keywords
Adult, Brain/diagnostic imaging, Brain/physiology, Female, Functional Neuroimaging/methods, Hot Temperature, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Male, Models, Statistical, Nociception/physiology, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2024 18:05
Last modification date
18/01/2024 15:10