Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease.

Détails

ID Serval
serval:BIB_4660CFC206BC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease.
Périodique
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Auteur(s)
Michalik L., Wahli W.
ISSN
1388-1981
ISSN-L
1879-2618
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
1771
Numéro
8
Pages
991-998
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Peroxisome proliferator-activated receptors, PPARalpha, PPARbeta/delta and PPARgamma, are fatty acid activated transcription factors that belong to the nuclear hormone receptor family. While they are best known as transcriptional regulators of lipid and glucose metabolism, evidence has also accumulated for their importance in skin homeostasis. The three PPAR isotypes are expressed in rodent and human skin. Various cell culture and in vivo approaches suggest that PPARalpha contributes to fetal skin development, to epidermal barrier maturation and to sebocyte activity. PPARbeta/delta regulates sebocyte differentiation, promotes hair follicle growth and has pro-differentiating effects in keratinocytes in normal and inflammatory conditions. In contrast, the role of PPARgamma appears to be rather minor in keratinocytes, whereas its activity is required for sebaceous gland differentiation. Importantly, PPARalpha and beta/delta are instrumental in skin repair after an injury, each of them playing specific roles. Due to their collective diverse functions in skin biology, PPARs represent a major research target for the understanding and treatment of many skin diseases, such as benign epidermal tumors, papillomas, acne vulgaris and psoriasis.
Mots-clé
Epidermis/physiology, Fetal Development, Hair Follicle/physiology, Humans, Melanocytes/physiology, PPAR alpha/physiology, PPAR delta/physiology, PPAR gamma/physiology, PPAR-beta/physiology, Peroxisome Proliferator-Activated Receptors/physiology, Skin/cytology, Skin/pathology, Skin Diseases/physiopathology, Skin Neoplasms/physiopathology, Skin Physiological Phenomena
Pubmed
Web of science
Création de la notice
24/01/2008 16:44
Dernière modification de la notice
03/03/2018 16:47
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