Effect of cisapride on gallbladder motility after extracorporeal shock-wave lithotripsy

Détails

ID Serval
serval:BIB_465D294781ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of cisapride on gallbladder motility after extracorporeal shock-wave lithotripsy
Périodique
Journal of Hepatology
Auteur(s)
Thorens  J., Schnegg  J. F., Brignoli  R., Froehlich  F., Jansen  J. B., Dorta  G., Blum  A. L., Gonvers  J. J., Fried  M.
ISSN
0168-8278 (Print)
Statut éditorial
Publié
Date de publication
03/1995
Volume
22
Numéro
3
Pages
333-7
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Mar
Résumé
BACKGROUND/AIMS: Altered gallbladder motility is regarded as one of the important factors involved in the formation and recurrence of gallstones. Previous studies have suggested that cisapride increases postprandial gallbladder contraction and may therefore be theoretically useful in preventing stone recurrence. The aim of our study was therefore to investigate the effect of cisapride on gallbladder motility in stone-free patients after extracorporeal shock-wave lithotripsy, as compared to healthy volunteers pair-matched for age and sex. METHODS: Each subject received cisapride or placebo in a double-blind, cross-over, random order. Gallbladder volumes were measured by ultrasonography in the fasting state and after intake of a standard liquid meal. Plasma cholecystokinin levels were determined by radioimmunoassay. RESULTS: Fasting gallbladder volumes were smaller in patients as compared to volunteers (20.7 +/- 1.3 ml vs. 46.0 +/- 9.2 ml; p < 0.05) but were not modified by cisapride (21.1 +/- 1.7 ml vs. 58.6 +/- 11.3 ml). The maximal postprandial decrease in gallbladder volume was similar in patients and volunteers (64.5 +/- 12% vs. 62 +/- 10%; NS) and was not significantly altered by cisapride (59 +/- 9.4% vs. 54 +/- 9%; NS). In patients, cisapride increased integrated postprandial gallbladder volume by accelerating gallbladder refilling as compared to placebo by 37 +/- 15% (p < 0.05). Integrated cholecystokinin plasma levels were similar in patients and volunteers and were 13.4 +/- 4.7% higher after cisapride as compared to placebo (p < 0.05). CONCLUSIONS: The results of this study suggest that cisapride does not alter postprandial gallbladder contraction but accelerates gallbladder refilling in patients free from gallstones after extracorporeal shock-wave lithotripsy. This effect of cisapride is probably due to an acceleration of gastric emptying also causing a secondary enhanced cholecystokinin release.
Mots-clé
Adult Aged Cholecystokinin/blood Cholelithiasis/blood/physiopathology/*therapy Cisapride Cross-Over Studies Double-Blind Method Female Gallbladder/*drug effects/physiopathology Humans *Lithotripsy Middle Aged Piperidines/blood/*pharmacology Radioimmunoassay
Pubmed
Web of science
Création de la notice
25/01/2008 16:48
Dernière modification de la notice
03/03/2018 16:47
Données d'usage