Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome.
Details
Serval ID
serval:BIB_4654204BDF48
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome.
Journal
Movement disorders
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
32
Number
4
Pages
605-609
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Few studies have investigated mortality risk in individuals with tic disorders.
We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person-years of follow-up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders.
The risk of premature death was higher among individuals with tic disorders (mortality rate ratio, 2.02; 95% CI, 1.49-2.66) and with Tourette syndrome (mortality rate ratio, 1.63; 95% CI, 1.11-2.28) compared with controls. After the exclusion of individuals with comorbid attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and substance abuse, tic disorder remained associated with increased mortality risk (mortality rate ratio, 2.30; 95% CI, 1.57-3.23), as did also Tourette Syndrome (mortality rate ratio, 1.81; 95% CI, 1.11-2.75).
These results are of clinical significance for clinicians and advocacy organizations. Several factors may contribute to this increased risk of premature death, and more research mapping out these factors is needed. © 2017 International Parkinson and Movement Disorder Society.
We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person-years of follow-up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders.
The risk of premature death was higher among individuals with tic disorders (mortality rate ratio, 2.02; 95% CI, 1.49-2.66) and with Tourette syndrome (mortality rate ratio, 1.63; 95% CI, 1.11-2.28) compared with controls. After the exclusion of individuals with comorbid attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and substance abuse, tic disorder remained associated with increased mortality risk (mortality rate ratio, 2.30; 95% CI, 1.57-3.23), as did also Tourette Syndrome (mortality rate ratio, 1.81; 95% CI, 1.11-2.75).
These results are of clinical significance for clinicians and advocacy organizations. Several factors may contribute to this increased risk of premature death, and more research mapping out these factors is needed. © 2017 International Parkinson and Movement Disorder Society.
Keywords
Adult, Age Distribution, Cohort Studies, Denmark/epidemiology, Female, Humans, Male, Registries, Sex Distribution, Tic Disorders/complications, Tic Disorders/epidemiology, Tic Disorders/mortality, Tourette Syndrome/complications, Tourette Syndrome/epidemiology, Tourette Syndrome/mortality, Young Adult, mortality, tic disorders, tourette syndrome
Pubmed
Web of science
Create date
12/02/2019 9:46
Last modification date
20/08/2019 13:51
Usage data
