Immunohistochemical localization of alpha- and betaA-subunits of inhibin/activin in human normal endocrine cells and related tumors of the digestive system.

Détails

ID Serval
serval:BIB_4650C491DEF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immunohistochemical localization of alpha- and betaA-subunits of inhibin/activin in human normal endocrine cells and related tumors of the digestive system.
Périodique
Virchows Archiv : An International Journal of Pathology
Auteur(s)
La Rosa S., Uccella S., Billo P., Facco C., Sessa F., Capella C.
ISSN
0945-6317 (Print)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
434
Numéro
1
Pages
29-36
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Activin A and inhibin A, first isolated from the ovary, are dimeric proteins able to modulate pituitary FSH secretion. Inhibin A is a heterodimer composed of one alpha-subunit and one betaA-subunit (alpha-betaA), while activin A is a homodimer of the betaA-subunit (betaA-betaA). Their identification in several tissues has suggested that they have numerous physiological functions, acting as either paracrine or autocrine factors. The aim of this study was to evaluate the expression of activin A and inhibin A in normal endocrine cells and in 70 endocrine tumours from different sites in the gastro-entero-pancreatic system, using specific monoclonal antibodies directed against the alpha- and betaA-subunits of inhibin/activin. Immunoreactivity for the betaA-subunit, but not for the alpha-subunit, was observed in normal G, EC, and GIP cells of the antrum and duodenum, and in pancreatic A cells. BetaA-subunit expression was observed in G cell and A cell tumours, and in a few insulinomas and ileal EC cell carcinoids. The alpha-subunit was found in rare cells in 7 of the 70 tumours and was colocalized with the betaA-subunit in only 1 tumor. Specific types of endocrine cells from the gut and pancreas appear to produce only activin A, a possible paracrine or autocrine modulator. Activin A is mainly produced by tumours derived from endocrine cells that normally express it.
Mots-clé
Activins, Adolescent, Adult, Aged, Digestive System Neoplasms/chemistry, Endocrine Gland Neoplasms/chemistry, Endocrine Glands/chemistry, Humans, Immunohistochemistry, Inhibins/analysis, Middle Aged
Pubmed
Web of science
Création de la notice
07/09/2016 9:38
Dernière modification de la notice
03/03/2018 16:47
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