Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited.

Détails

ID Serval
serval:BIB_4630FDB70D9A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited.
Périodique
Physiological Reviews
Auteur(s)
Rossier B.C., Baker M.E., Studer R.A.
ISSN
1522-1210 (Electronic)
ISSN-L
0031-9333
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
95
Numéro
1
Pages
297-340
Langue
anglais
Notes
Publication types: Journal Article ; Portraits ; Review Publication
Résumé
Transcription and translation require a high concentration of potassium across the entire tree of life. The conservation of a high intracellular potassium was an absolute requirement for the evolution of life on Earth. This was achieved by the interplay of P- and V-ATPases that can set up electrochemical gradients across the cell membrane, an energetically costly process requiring the synthesis of ATP by F-ATPases. In animals, the control of an extracellular compartment was achieved by the emergence of multicellular organisms able to produce tight epithelial barriers creating a stable extracellular milieu. Finally, the adaptation to a terrestrian environment was achieved by the evolution of distinct regulatory pathways allowing salt and water conservation. In this review we emphasize the critical and dual role of Na(+)-K(+)-ATPase in the control of the ionic composition of the extracellular fluid and the renin-angiotensin-aldosterone system (RAAS) in salt and water conservation in vertebrates. The action of aldosterone on transepithelial sodium transport by activation of the epithelial sodium channel (ENaC) at the apical membrane and that of Na(+)-K(+)-ATPase at the basolateral membrane may have evolved in lungfish before the emergence of tetrapods. Finally, we discuss the implication of RAAS in the origin of the present pandemia of hypertension and its associated cardiovascular diseases.
Mots-clé
Aldosterone/metabolism, Animals, Biological Evolution, Epithelial Sodium Channels/chemistry, Epithelial Sodium Channels/genetics, Genome, Human, Humans, Nephrons/physiology, Signal Transduction/physiology, Sodium/metabolism, Sodium-Potassium-Exchanging ATPase/chemistry, Sodium-Potassium-Exchanging ATPase/genetics
Pubmed
Web of science
Création de la notice
28/04/2015 18:28
Dernière modification de la notice
03/03/2018 16:47
Données d'usage