The effect of short-term indomethacin therapy on amniotic fluid volume

Détails

ID Serval
serval:BIB_460E52546BA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The effect of short-term indomethacin therapy on amniotic fluid volume
Périodique
American Journal of Obstetrics and Gynecology
Auteur(s)
Sandruck  J. C., Grobman  W. A., Gerber  S. E.
ISSN
0002-9378 (Print)
Statut éditorial
Publié
Date de publication
05/2005
Volume
192
Numéro
5
Pages
1443-5
Notes
Clinical Trial
Journal Article --- Old month value: May
Résumé
OBJECTIVE: The purpose of this study was to determine the effect of short-term (48 hour) indomethacin therapy on amniotic fluid volume. STUDY DESIGN: Patients who were admitted to Northwestern Memorial Hospital in preterm labor and who received indomethacin tocolysis were eligible for the study. Thirty-five patients with singleton gestations and 26 patients with twin gestations were enrolled. Amniotic fluid volumes were measured at baseline, at 48 hours after the initiation of indomethacin, and then every 24 hours thereafter for a maximum of 7 days. RESULTS: There were no significant changes in mean amniotic fluid volume subsequent to the administration of indomethacin at any of the time points that were measured. Among the 61 patients who received indomethacin, there were 2 cases of oligohydramnios (3.3%; 95% CI, 0.03%, 11.3%). In both cases, the amniotic fluid index returned to normal within 24 hours after the discontinuation of indomethacin. CONCLUSION: Short-term indomethacin therapy, in either singleton or twin gestations, does not cause a clinically significant change in amniotic fluid volume.
Mots-clé
Amniotic Fluid/*drug effects/*metabolism Drug Administration Schedule Female Humans Incidence Indomethacin/*administration & dosage/*adverse effects/therapeutic use Obstetric Labor, Premature/*drug therapy Oligohydramnios/chemically induced/epidemiology/metabolism Pregnancy Pregnancy, Multiple Time Factors Tocolytic Agents/*administration & dosage/*adverse effects/therapeutic use Treatment Outcome Twins
Pubmed
Web of science
Création de la notice
25/01/2008 16:44
Dernière modification de la notice
03/03/2018 16:47
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