IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.

Détails

ID Serval
serval:BIB_460BA13D68A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.
Périodique
Developmental Cell
Auteur(s)
Brisken C., Ayyannan A., Nguyen C., Heineman A., Reinhardt F., Tan J., Dey S.K., Dotto G.P., Weinberg R.A., Jan T.
ISSN
1534-5807 (Print)
ISSN-L
1534-5807
Statut éditorial
Publié
Date de publication
2002
Volume
3
Numéro
6
Pages
877-887
Langue
anglais
Résumé
The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly understood. We show that cyclin D1(-/-) MECs fail to proliferate in response to prolactin and identify IGF-2 as a downstream target of prolactin signaling that lies upstream of cyclin D1 transcription. Ectopic IGF-2 expression restores alveologenesis in prolactin receptor(-/-) epithelium. Alveologenesis is retarded in IGF-2-deficient MECs. IGF-2 and prolactin receptor mRNAs colocalize in the mammary epithelium. Prolactin induces IGF-2 mRNA and IGF-2 induces cyclin D1 protein in primary MECs. Thus, IGF-2 is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland.
Mots-clé
Animals, Breast Neoplasms/genetics, Carcinoma/genetics, Carrier Proteins, Cell Division/genetics, Cells, Cultured, Cyclin D1/deficiency, Cyclin D1/genetics, Epithelial Cells/cytology, Epithelial Cells/drug effects, Female, Gene Expression Regulation, Developmental/genetics, Genes/drug effects, Genes/genetics, Genetic Testing, Insulin-Like Growth Factor II/genetics, Insulin-Like Growth Factor II/metabolism, Mammary Glands, Animal/cytology, Mammary Glands, Animal/embryology, Membrane Glycoproteins, Mice, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Progesterone/metabolism, Progesterone/pharmacology, Prolactin/genetics, Prolactin/metabolism, RANK Ligand, RNA, Messenger/genetics, RNA, Messenger/metabolism, Receptor Activator of Nuclear Factor-kappa B, Receptors, Progesterone/deficiency, Receptors, Progesterone/genetics, Signal Transduction/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:58
Dernière modification de la notice
08/05/2019 17:55
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