Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_45FDB7F07C80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.
Périodique
Cancer Causes and Control
Auteur(s)
Toriola Adetunji T., Surcel Helja-Marja, Lundin Eva, Schock Helena, Grankvist Kjell, Pukkala Eero, Chen Tianhui, Toniolo Paolo, Lehtinen Matti, Zeleniuch-Jacquotte Anne, Lukanova Annekatrin
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
22
Numéro
11
Pages
1607-1611
Langue
anglais
Résumé
BACKGROUND: Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). METHODS: A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. RESULTS: Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). CONCLUSIONS: Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
Pubmed
Web of science
Création de la notice
17/08/2011 17:06
Dernière modification de la notice
03/03/2018 16:46
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