Effect of expiratory positive airway pressure on sleep disordered breathing.

Détails

ID Serval
serval:BIB_45F2449D9E24
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of expiratory positive airway pressure on sleep disordered breathing.
Périodique
Sleep
Auteur(s)
Heinzer R., White D.P., Malhotra A., Lo Y.L., Dover L., Stevenson K.E., Jordan A.S.
ISSN
0161-8105
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
31
Numéro
3
Pages
429-432
Langue
anglais
Résumé
STUDY OBJECTIVES: We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients. DESIGN: Observational physiology study PARTICIPANTS: We studied 10 OSA patients during sleep wearing a facial mask. We recorded 1 hour of NREM sleep without treatment (baseline) and 1 hour with 10 cm H2O EPAP in random order, while measuring EELV and breathing pattern. RESULTS: The mean EELV change between baseline and EPAP was only 13.3 mL (range 2-25 mL). Expiratory time was significantly increased with EPAP compared to baseline 2.64 +/- 0.54 vs 2.16 +/- 0.64 sec (P = 0.002). Total respiratory time was longer with EPAP than at baseline 4.44 +/- 1.47 sec vs 3.73 +/- 0.88 sec (P = 0.3), and minute ventilation was lower with EPAP vs baseline 7.9 +/- 4.17 L/min vs 9.05 +/- 2.85 L/min (P = 0.3). For baseline (no treatment) and EPAP respectively, the mean apnea+hypopnea index (AHI) was 62.6 +/- 28.7 and 56.8 +/- 30.3 events per hour (P = 0.4). CONCLUSION: In OSA patients during sleep, the application of 10 cm H2O EPAP led to prolongation of expiratory time with only marginal increases in FRC. These findings suggest important mechanisms exist to avoid hyperinflation during sleep.
Mots-clé
Adult, Airway Resistance/physiology, Body Mass Index, Expiratory Reserve Volume/physiology, Female, Functional Residual Capacity/physiology, Humans, Male, Middle Aged, Oxygen/blood, Polysomnography, Positive-Pressure Respiration, Sleep Apnea, Obstructive/diagnosis, Sleep Apnea, Obstructive/physiopathology, Tidal Volume/physiology
Pubmed
Web of science
Création de la notice
02/10/2009 18:38
Dernière modification de la notice
03/03/2018 16:46
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