Immunoscintigraphy with biosynthetically-labeled 75Se-antibodies--I. Biodistribution of 75Se-monoclonal antibodies and of free radionuclide

Détails

ID Serval
serval:BIB_45DF14866093
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immunoscintigraphy with biosynthetically-labeled 75Se-antibodies--I. Biodistribution of 75Se-monoclonal antibodies and of free radionuclide
Périodique
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
Auteur(s)
Ryser  J. E., Carrel  S., Buchegger  F., Donath  A.
ISSN
0969-8051
0883-2897 (Print)
Statut éditorial
Publié
Date de publication
1990
Volume
17
Numéro
5
Pages
487-94
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Biosynthetically-radiolabeled MoAbs provide a tool to test whether structural modifications of the MoAbs influence the results of conventional immunoscintigraphy. When biosynthetically-labeled 75Se-MoAbs from the Mel-14 hybridoma were injected into mice with melanoma xenografts, the high tumor recovery supported the hypothesis of a structural advantage. The increased excretion of 75Se obtained by supplementing the diet of the mice with cold selenium did not reduce the tumor recovery, demonstrating an accumulation of the free radionuclide in normal tissue.
Mots-clé
Administration, Oral Animals Antibodies, Monoclonal/diagnostic use/*pharmacokinetics Antigens, Neoplasm/*immunology Humans Isotope Labeling/methods Melanoma/immunology/*metabolism/radionuclide imaging Mice Mice, Nude Neoplasm Transplantation Selenium/administration & dosage Selenium Radioisotopes/diagnostic use/*pharmacokinetics Tissue Distribution Transplantation, Heterologous
Pubmed
Création de la notice
25/01/2008 12:28
Dernière modification de la notice
03/03/2018 16:46
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