Is Favorable Outcome Possible After Prolonged Refractory Status Epilepticus?

Détails

Ressource 1Télécharger: BIB_45DC74A7ACB6.P001.pdf (538.42 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_45DC74A7ACB6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Is Favorable Outcome Possible After Prolonged Refractory Status Epilepticus?
Périodique
Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Auteur(s)
Alvarez V., Drislane F.W.
ISSN
1537-1603 (Electronic)
ISSN-L
0736-0258
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
33
Numéro
1
Pages
32-41
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Résumé
When status epilepticus (SE) remains refractory to appropriate therapy, it is associated with high mortality and with substantial morbidity in survivors. Many outcome predictors such as age, seizure type, level of consciousness before treatment, and mostly, etiology, are well-established. A longer duration of SE is often associated with worse outcome, but duration may lose its prognostic value after several hours. Several terms and definitions have been used to describe prolonged, refractory SE, including "malignant SE," "prolonged" SE, and more recently, "super refractory" SE, defined as "SE that has continued or recurred despite 24 hours of general anesthesia (or coma-inducing anticonvulsants)." There are few data available regarding the outcome of prolonged refractory SE, and even fewer for SE remaining refractory to anesthetic drugs. This article reviews reports of outcome after prolonged, refractory, and "super refractory" SE. Most information detailing the clinical outcome of patients surviving these severe illnesses, in which seizures can persist for days or weeks (and especially those concerning "super-refractory" SE) come from case reports and retrospective cohort studies. In many series, prolonged, refractory SE has a mortality of 30% to 50%, and several studies indicate that most survivors have a substantial decline in functional status. Nevertheless, several reports demonstrate that good functional outcome is possible even after several days of SE and coma induction. Treatment of refractory SE should not be withdrawn from younger patients without structural brain damage at presentation solely because of the duration of SE.
Mots-clé
Age Distribution, Anesthetics/therapeutic use, Anticonvulsants/therapeutic use, Chronic Disease, Evidence-Based Medicine, Humans, Prevalence, Prognosis, Risk Factors, Sex Distribution, Status Epilepticus/mortality, Status Epilepticus/prevention & control, Survival Rate, Treatment Failure, Treatment Outcome
Pubmed
Web of science
Création de la notice
16/02/2016 18:17
Dernière modification de la notice
03/03/2018 16:46
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