Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.

Marchal, A.; Cirulli, E.T.; Neveux, I.; Bellos, E.; Thwaites, R.S.; Schiabor Barrett, K.M.; Zhang, Y.; Nemes-Bokun, I.; Kalinova, M.; Catchpole, A.; Tangye, S.G.; Spaan, A.N.; Lack, J.B.; Ghosn, J.; Burdet, C.; Gorochov, G.; Tubach, F.; Hausfater, P.; Dalgard, C.L.; Zhang, S.Y.; Zhang, Q.; Chiu, C.; Fellay, J.; Grzymski, J.J.; Sancho-Shimizu, V.; Abel, L.; Casanova, J.L.; Cobat, A.; Bolze, A.

doi:10.1016/j.xhgg.2024.100300

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.

Details

Download: 38678364.pdf (2460.26 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_45B960D632E8

Type

Article: article from journal or magazin.

Publication sub-type

Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.

Collection

Publications

Institution

UNIL/CHUV

Title

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.

Journal

HGG advances

Author(s)

Marchal A., Cirulli E.T., Neveux I., Bellos E., Thwaites R.S., Schiabor Barrett K.M., Zhang Y., Nemes-Bokun I., Kalinova M., Catchpole A., Tangye S.G., Spaan A.N., Lack J.B., Ghosn J., Burdet C., Gorochov G., Tubach F., Hausfater P., Dalgard C.L., Zhang S.Y., Zhang Q., Chiu C., Fellay J., Grzymski J.J., Sancho-Shimizu V., Abel L., Casanova J.L., Cobat A., Bolze A.

Working group(s)

COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group

ISSN

2666-2477 (Electronic)

ISSN-L

2666-2477

Publication state

Published

Issued date

25/07/2024

Peer-reviewed

Oui

Volume

Number

Pages

100300

Language

english

Abstract

Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the US (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B*15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.

URN

urn:nbn:ch:serval-BIB_45B960D632E85

OAI-PMH

oai:serval.unil.ch:BIB_45B960D632E8

DOI

10.1016/j.xhgg.2024.100300

Pubmed

38678364

Web of science

001261339200001

Open Access

Yes