Functional avidity-driven activation-induced cell death shapes CTL immunodominance.

Détails

ID Serval
serval:BIB_459CA3A5C32E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Functional avidity-driven activation-induced cell death shapes CTL immunodominance.
Périodique
Journal of Immunology (baltimore, Md. : 1950)
Auteur(s)
Dalla Santa S., Merlo A., Bobisse S., Ronconi E., Boldrin D., Milan G., Barbieri V., Marin O., Facchinetti A., Biasi G., Dolcetti R., Zanovello P., Rosato A.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
193
Numéro
9
Pages
4704-4711
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Immunodominance is a complex phenomenon that relies on a mere numerical concept, while being potentially influenced at every step of the immune response. We investigated the mechanisms leading to the establishment of CTL immunodominance in a retroviral model and found that the previously defined subdominant Env-specific CD8(+) T cells are endowed with an unexpectedly higher functional avidity than is the immunodominant Gag-recognizing counterpart. This high avidity, along with the Env Ag overload, results in a supraoptimal TCR engagement. The overstimulation makes Env-specific T lymphocytes more susceptible to apoptosis, thus hampering their expansion and leading to an unintentional "immune kamikazing." Therefore, Ag-dependent, hyperactivation-induced cell death can be regarded as a novel mechanism in the establishment of the immunodominance that restrains and opposes the expansion of high-avidity T cells in favor of lower-affinity populations.
Mots-clé
Animals, Antigens, Viral/immunology, Apoptosis/immunology, Cell Line, Cytotoxicity, Immunologic, Female, Gene Products, env/immunology, Gene Products, gag/immunology, Humans, Immunodominant Epitopes/immunology, Lymphocyte Activation/immunology, Mice, Retroviridae/immunology, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Cytotoxic/metabolism
Pubmed
Web of science
Création de la notice
18/10/2016 17:21
Dernière modification de la notice
03/03/2018 16:46
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