Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease.
Details
Serval ID
serval:BIB_458485CA16A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease.
Journal
Alimentary pharmacology & therapeutics
Working group(s)
Swiss IBD cohort study group
Contributor(s)
Anderegg C., Bauerfeind P., Beglinger C., Belli D., Bengoa J.M., Bigler B., Binek J., Blattmann M., Boehm S., Borovicka J., Braegger C.P., Brunner N., Bühr P., Burnand B., Burri E., Buyse S., Cremer M., Criblez D.H., de Saussure P., Degen L., Delarive J., Doerig C., Dora B., Dorta G., Egger M., Ehmann T., El-Wafa A., Engelmann M., Ezri J., Felley C., Fliegner M., Fournier N., Fraga M., Frei P., Frei R., Fried M., Froehlich F., Funk C., Furlano R.I., Gallot-Lavallée S., Geyer M., Girardin M., Golay D., Grandinetti T., Gysi B., Haack H., Haarer J., Helbling B., Hengstler P., Herzog D., Hess C., Heyland K., Hinterleitner T., Hiroz P., Hirschi C., Hruz P., Iwata R., Jost R., Juillerat P., Brondolo V.K., Knellwolf C., Knoblauch C., Köhler H., Koller R., Krieger-Grübel C., Kullak-Ublick G., Künzler P., Landolt M., Lange R., Lehmann F.S., Macpherson A., Maerten P., Maillard M.H., Manser C., Manz M., Marbet U., Marx G., Matter C., McLin V., Meier R., Mendanova M., Meyenberger C., Michetti P., Moradpour D., Morell B., Mosler P., Mottet C., Müller C., Müller P., Müllhaupt B., Münger-Beyeler C., Musso L., Nagy A., Neagu M., Nichita C., Niess J., Noël N., Nydegger A., Obialo N., Oneta C., Oropesa C., Peter U., Peternac D., Petit L.M., Piccoli-Gfeller F., Pilz J.B., Pittet V., Raschle N., Rentsch R., Restellini S., Richterich J.P., Rihs S., Ritz M.A., Roduit J., Rogler D., Rossel J.B., Sagmeister M., Saner G., Sauter B., Sawatzki M., Schäppi M., Scharl M., Schelling M., Schibli S., Schlauri H., Uebelhart S.S., Schnegg J.F., Schoepfer A., Seibold F., Seirafi M., Semadeni G.M., Semela D., Senning A., Sidler M., Sokollik C., Spalinger J., Spangenberger H., Stadler P., Steuerwald M., Straumann A., Straumann-Funk B., Thorens J., Tiedemann S., Tutuian R., Vavricka S., Viani F., Vögtlin J., Vonlaufen A., Vouillamoz D., Vulliamy R., Wermuth J., Werner H., Wiesel P., Wiest R., Wylie T., Zeitz J., Zimmermann D.
ISSN
1365-2036 (Electronic)
ISSN-L
0269-2813
Publication state
Published
Issued date
07/2021
Peer-reviewed
Oui
Volume
54
Number
1
Pages
53-67
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease.
To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course.
We tested for associations between Type D (Type D Scale-14), depressive symptoms (Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross-sectional and Cox proportional hazards models for time-to-event analyses. IBD disease course was assessed by the future occurrence of active disease (Crohn's Disease Activity Index ≥150/Modified Truelove & Witts activity index ≥10) and several IBD-relevant endpoints.
Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97-1.79, q = 0.292).
Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.
To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course.
We tested for associations between Type D (Type D Scale-14), depressive symptoms (Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross-sectional and Cox proportional hazards models for time-to-event analyses. IBD disease course was assessed by the future occurrence of active disease (Crohn's Disease Activity Index ≥150/Modified Truelove & Witts activity index ≥10) and several IBD-relevant endpoints.
Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97-1.79, q = 0.292).
Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.
Keywords
Anxiety/epidemiology, Anxiety/etiology, Colitis, Ulcerative, Cross-Sectional Studies, Depression/epidemiology, Depression/etiology, Humans, Inflammatory Bowel Diseases/complications, Inflammatory Bowel Diseases/epidemiology, Type D Personality
Pubmed
Web of science
Create date
20/07/2021 10:30
Last modification date
05/11/2021 13:32
Usage data
