A New CRB1 Rat Mutation Links Müller Glial Cells to Retinal Telangiectasia.

Détails

Ressource 1Télécharger: BIB_4583A5612DA1.P001.pdf (2215.95 [Ko])
Etat: Serval
Version: Author's accepted manuscript
Document(s) secondaire(s)
Télécharger: 6093.full.pdf (4632.14 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_4583A5612DA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A New CRB1 Rat Mutation Links Müller Glial Cells to Retinal Telangiectasia.
Périodique
Journal of Neuroscience
Auteur(s)
Zhao M., Andrieu-Soler C., Kowalczuk L., Paz Cortés M., Berdugo M., Dernigoghossian M., Halili F., Jeanny J.C., Goldenberg B., Savoldelli M., El Sanharawi M., Naud M.C., van Ijcken W., Pescini-Gobert R., Martinet D., Maass A., Wijnholds J., Crisanti P., Rivolta C., Behar-Cohen F.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
35
Numéro
15
Pages
6093-6106
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
We have identified and characterized a spontaneous Brown Norway from Janvier rat strain (BN-J) presenting a progressive retinal degeneration associated with early retinal telangiectasia, neuronal alterations, and loss of retinal Müller glial cells resembling human macular telangiectasia type 2 (MacTel 2), which is a retinal disease of unknown cause. Genetic analyses showed that the BN-J phenotype results from an autosomal recessive indel novel mutation in the Crb1 gene, causing dislocalization of the protein from the retinal Müller glia (RMG)/photoreceptor cell junction. The transcriptomic analyses of primary RMG cultures allowed identification of the dysregulated pathways in BN-J rats compared with wild-type BN rats. Among those pathways, TGF-β and Kit Receptor Signaling, MAPK Cascade, Growth Factors and Inflammatory Pathways, G-Protein Signaling Pathways, Regulation of Actin Cytoskeleton, and Cardiovascular Signaling were found. Potential molecular targets linking RMG/photoreceptor interaction with the development of retinal telangiectasia are identified. This model can help us to better understand the physiopathologic mechanisms of MacTel 2 and other retinal diseases associated with telangiectasia.
Pubmed
Web of science
Création de la notice
21/04/2015 10:58
Dernière modification de la notice
19/03/2018 10:50
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