Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Détails

ID Serval
serval:BIB_457247D2740B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Périodique
Nature Medicine
Auteur(s)
Sistigu A., Yamazaki T., Vacchelli E., Chaba K., Enot D.P., Adam J., Vitale I., Goubar A., Baracco E.E., Remédios C., Fend L., Hannani D., Aymeric L., Ma Y., Niso-Santano M., Kepp O., Schultze J.L., Tüting T., Belardelli F., Bracci L., La Sorsa V., Ziccheddu G., Sestili P., Urbani F., Delorenzi M., Lacroix-Triki M., Quidville V., Conforti R., Spano J.P., Pusztai L., Poirier-Colame V., Delaloge S., Penault-Llorca F., Ladoire S., Arnould L., Cyrta J., Dessoliers M.C., Eggermont A., Bianchi M.E., Pittet M., Engblom C., Pfirschke C., Préville X., Uzè G., Schreiber R.D., Chow M.T., Smyth M.J., Proietti E., André F., Kroemer G., Zitvogel L.
ISSN
1546-170X (Electronic)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
20
Numéro
11
Pages
1301-1309
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-α and IFN-β receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking Tlr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
Pubmed
Web of science
Création de la notice
11/12/2014 19:09
Dernière modification de la notice
03/03/2018 16:45
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