Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period: a new swine model of pulmonary vascular disease.

Détails

ID Serval
serval:BIB_455E85446913
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period: a new swine model of pulmonary vascular disease.
Périodique
American journal of physiology. Heart and circulatory physiology
Auteur(s)
de Wijs-Meijler DPM, van Duin RWB, Duncker D.J., Scherrer U., Sartori C., Reiss IKM, Merkus D.
ISSN
1522-1539 (Electronic)
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
01/03/2018
Peer-reviewed
Oui
Volume
314
Numéro
3
Pages
H603-H615
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Pulmonary vascular disease (PVD) represents an underestimated and increasing clinical burden not only in the neonatal period but also later in life, when exercise tolerance is decreased. Animal models performing long-term followup after a perinatal insult are lacking. This study aimed to develop and characterize a neonatal swine model with hypoxia-induced PVD during long-term followup after reexposure to normoxia and to investigate the exercise response in this model. Piglets were exposed to a normoxic ( n = 10) or hypoxic environment ( n = 9) for 4 wk. Neonatal hypoxia exposure resulted in pulmonary hypertension. Mean pulmonary artery pressure was elevated 1 day after reexposure to normoxia (30.2 ± 3.3 vs. 14.3 ± 0.9 mmHg) and remained significantly higher in the second week (32.8 ± 3.8 vs. 21.4 ± 1.2 mmHg), accompanied by decreased exercise tolerance. Exercise resulted in a trend toward an exaggerated increase of pulmonary artery pressure in hypoxia-exposed animals ( week 6, P = 0.086). Although pulmonary hypertension was transient, thickening of pulmonary arterioles was found at the end of followup. Furthermore, right ventricular dilation, lower right ventricular fractional area change ( week 8, 40.0 ± 2.7% vs. 29.5 ± 4.7%), and tricuspid annular plane systolic excursion ( week 8, 27.0 ± 2.5 vs. 22.9 ± 2.1 mm) persisted during followup. Male animals showed more severe PVD than female animals. In conclusion, we developed a neonatal swine model that allows examination of the long-term sequelae of damage to the developing neonatal lung, the course of the disease and the effect of therapy on long-term outcome. NEW & NOTEWORTHY The swine model of neonatal pulmonary vascular disease developed in the present study is the first that allows exercise testing and examination of long-term sequelae of a perinatal hypoxic insult, the course of the disease, and the effect of therapy on long-term outcome.
Mots-clé
Animals, Animals, Newborn, Arterial Pressure, Disease Models, Animal, Disease Progression, Echocardiography, Exercise Tolerance, Female, Hyperoxia/complications, Hyperoxia/pathology, Hyperoxia/physiopathology, Hypertension, Pulmonary/diagnostic imaging, Hypertension, Pulmonary/etiology, Hypertension, Pulmonary/pathology, Hypertension, Pulmonary/physiopathology, Hypertrophy, Right Ventricular/etiology, Hypertrophy, Right Ventricular/pathology, Hypertrophy, Right Ventricular/physiopathology, Male, Pulmonary Artery/diagnostic imaging, Pulmonary Artery/pathology, Pulmonary Artery/physiopathology, Sex Factors, Sus scrofa, Time Factors, Vascular Remodeling, Ventricular Dysfunction, Right/etiology, Ventricular Dysfunction, Right/pathology, Ventricular Dysfunction, Right/physiopathology, Ventricular Function, Right, exercise, hypoxia, perinatal programming, pulmonary vascular disease, sex
Pubmed
Web of science
Création de la notice
17/01/2018 11:39
Dernière modification de la notice
07/02/2019 7:26
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