RXRs: collegial partners.

Détails

ID Serval
serval:BIB_454B4EC06530
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Titre
RXRs: collegial partners.
Titre du livre
The biochemistry of retinoic acid receptors I: structure, activation, and function at the molecular level
Auteur(s)
Gilardi F., Desvergne B.
Editeur
Springer
Lieu d'édition
Dordrecht
ISBN
978-94-017-9050-5
Statut éditorial
Publié
Date de publication
2014
Editeur scientifique
Asson-Batres M.A., Rochette-Egly C.
Volume
70
Série
Subcellular Biochemistry
Numéro de chapitre
5
Pages
75-102
Langue
anglais
Résumé
Retinoid X Receptors (RXR) were initially identified as nuclear receptors binding with stereo-selectivity the vitamin A derivative 9-cis retinoic acid, although the relevance of this molecule as endogenous activator of RXRs is still elusive. Importantly, within the nuclear receptor superfamily, RXRs occupy a peculiar place, as they are obligatory partners for a number of other nuclear receptors, thus integrating the corresponding signaling pathways. In this chapter, we describe the structural features allowing RXR to form homo- and heterodimers, and the functional consequences of this unique ability. Furthermore, we discuss the importance of studying RXR activity at a genome-wide level in order to comprehensively address the biological implications of their action that is fundamental to understand to what extent RXRs could be exploited as new therapeutic targets.
Mots-clé
Animals, Gene Expression Regulation, Humans, Ligands, Mice, Protein Binding, Protein Isoforms/genetics, Protein Isoforms/metabolism, Protein Multimerization, Protein Structure, Tertiary, Receptors, Retinoic Acid/genetics, Receptors, Retinoic Acid/metabolism, Response Elements, Retinoid X Receptors/genetics, Retinoid X Receptors/metabolism, Signal Transduction, Tretinoin/chemistry, Tretinoin/metabolism
Pubmed
Web of science
Création de la notice
15/02/2015 22:36
Dernière modification de la notice
03/03/2018 16:45
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