Pituitary Tumors: Pathology and Genetics

Détails

ID Serval
serval:BIB_447253A5E7A9
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Titre
Pituitary Tumors: Pathology and Genetics
Titre du livre
Encyclopedia of Cancer
Auteur(s)
La Rosa S., Uccella S.
Editeur
Elsevier
ISBN
9780128012383
Statut éditorial
Publié
Date de publication
2018
Série
Reference Module in Biomedical Sciences
Pages
241-256
Edition
3r ed.
Langue
anglais
Résumé
Tumors of the pituitary gland are frequent intracranial neoplasms. They can affect all ages and show a slight prevalence in females. Clinically, they can present either with signs and symptoms of pituitary hormone hypersecretion, or as space-occupying intracranial masses, with visual defects and headaches as the main symptoms. Rarely, neoplasms in this site may cause hypopituitarism.
Pituitary adenomas represent the most common form of pituitary neoplasms. They are slow-growing, non-metastasizing proliferations of adenohypophyseal cells, although they can show an invasive attitude towards the adjacent bony and vascular structures. The pathogenetic basis of pituitary adenomas does not involve classical oncogenes and tumor suppressor genes, but rather a number of alterations of cell signaling, cell cycle regulators, transcriptional regulators and miRNAs. The diagnosis and classification of pituitary adenomas is largely based on immunohistochemical analyses, with pituitary hormones and specific pituitary-cell lineage transcription factors being the most important markers.
Rare pituitary tumors, including pituitary carcinoma, pituitary blastoma, tumors of the neurohypophysis, neuronal and paraneuronal tumors, mesenchymal and stromal tumors, hematological tumors, germ cell tumors and mixed neuroendocrine–nonneuroendocrine tumors are also discussed in this article.
Mots-clé
Adenoma, Carcinoma, Corticotroph, Genetics, Gonadotroph, Lactotroph, Molecular pathology, Morphology, Pathology, Pituitary, Somatotroph, Thyrotroph
Création de la notice
23/11/2018 8:39
Dernière modification de la notice
20/08/2019 13:48
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