Selection for recombination in structured populations.

Details

Serval ID
serval:BIB_4453FBEA3F75
Type
Article: article from journal or magazin.
Collection
Publications
Title
Selection for recombination in structured populations.
Journal
Genetics
Author(s)
Martin G., Otto S.P., Lenormand T.
ISSN
0016-6731 (Print)
ISSN-L
0016-6731
Publication state
Published
Issued date
01/2006
Peer-reviewed
Oui
Volume
172
Number
1
Pages
593-609
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In finite populations, linkage disequilibria generated by the interaction of drift and directional selection (Hill-Robertson effect) can select for sex and recombination, even in the absence of epistasis. Previous models of this process predict very little advantage to recombination in large panmictic populations. In this article we demonstrate that substantial levels of linkage disequilibria can accumulate by drift in the presence of selection in populations of any size, provided that the population is subdivided. We quantify (i) the linkage disequilibrium produced by the interaction of drift and selection during the selective sweep of beneficial alleles at two loci in a subdivided population and (ii) the selection for recombination generated by these disequilibria. We show that, in a population subdivided into n demes of large size N, both the disequilibrium and the selection for recombination are equivalent to that expected in a single population of a size intermediate between the size of each deme (N) and the total size (nN), depending on the rate of migration among demes, m. We also show by simulations that, with small demes, the selection for recombination is stronger than both that expected in an unstructured population (m = 1 - 1/n) and that expected in a set of isolated demes (m = 0). Indeed, migration maintains polymorphisms that would otherwise be lost rapidly from small demes, while population structure maintains enough local stochasticity to generate linkage disequilibria. These effects are also strong enough to overcome the twofold cost of sex under strong selection when sex is initially rare. Overall, our results show that the stochastic theories of the evolution of sex apply to a much broader range of conditions than previously expected.
Keywords
Alleles, Animals, Epistasis, Genetic, Evolution, Molecular, Female, Genetic Drift, Genetic Linkage, Genetics, Population, Humans, Linkage Disequilibrium, Male, Models, Genetic, Models, Theoretical, Recombination, Genetic, Selection, Genetic, Sex Distribution
Pubmed
Web of science
Create date
19/11/2007 11:24
Last modification date
24/07/2023 16:07
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