Effects of oestrogens on prolactin and thyrotrophin responses to TRH in women during the menstrual cycle and under oral contraceptive treatment

Details

Serval ID
serval:BIB_4407D3E93790
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of oestrogens on prolactin and thyrotrophin responses to TRH in women during the menstrual cycle and under oral contraceptive treatment
Journal
Clinical Endocrinology
Author(s)
Reymond  M., Lemarchand-Beraud  T.
ISSN
0300-0664
Publication state
Published
Issued date
09/1976
Peer-reviewed
Oui
Volume
5
Number
5
Pages
429-37
Notes
Journal Article --- Old month value: Sep
Abstract
The effects of physiological and pharmacological variations of oestrogens on prolactin and thyrotrophin (TSH) secretion have been studied during the menstrual cycle and under oral contraceptive treatment. Ten women were tested for prolactin and TSH responses to 200 mug TRH in the early follicular (days 4-6), periovulatory (days 14-15) and luteal phases (days 22-26) of the same menstrual cycle. Circulating plasma prolactin levels did not significantly vary in the three phases, but TSH basal levels were lower in the luteal than in the follicular and periovulatory periods. The prolactin response to TRH was significantly enhanced in the periovulatory phase, while the TSH response was slightly decreased. Seven women on sequential contraceptives exhibited increased basal and TRH-induced prolactin secretion during the oestrogen treatment, with an unaltered TSH secretion throughout therapy. Treatment with combined contraceptives did not alter either basal or TRH-induced prolactin secretion in eight women, but basal TSH secretion and its response to TRH were both reduced. These data show that oestrogens may produce different regulatory effects on prolactin and TSH secretion, particularly in the pituitary sensitivity to TRH stimulation. Physiological variations of oestrogen secretion such as those observed during the menstrual cycle can likewise modify prolactin levels. These results could provide some support for a regulatory role for prolactin in the menstrual cycle.
Keywords
Adult Contraceptives, Oral/*pharmacology Contraceptives, Oral, Combined/pharmacology Contraceptives, Oral, Sequential/pharmacology Estrogens/*pharmacology Ethinyl Estradiol/pharmacology Female Humans Menstruation/drug effects Prolactin/blood/*secretion Thyrotropin/blood/*secretion Thyrotropin-Releasing Hormone/blood/*pharmacology
Pubmed
Web of science
Create date
11/02/2008 14:12
Last modification date
20/08/2019 13:48
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