The effects of tranexamic acid on blood loss and transfusion rate in colorectal surgery.

Details

Ressource 1Download: 1-s2.0-S0002961019301734-main.pdf (333.89 [Ko])
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_43EAB8A8AF2A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The effects of tranexamic acid on blood loss and transfusion rate in colorectal surgery.
Journal
American journal of surgery
Author(s)
Grass F., Braafladt S., Alabbad J., Lovely J.K., Kelley S.R., Mathis K.L., Huebner M., Larson D.W.
ISSN
1879-1883 (Electronic)
ISSN-L
0002-9610
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
218
Number
5
Pages
876-880
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The present study aimed to evaluate safety of tranexamic acid (TA) administration and to assess bleeding risk in colorectal surgery (CRS).
Retrospective cohort study including consecutive patients undergoing elective CRS by a single surgeon between August 2014 and May 2015. All patients received 1 g of TA intravenously at induction and at closure. Demographics, operative and postoperative details were prospectively assessed and compared to a historical control cohort.
213 patients were evaluated. TA did not increase complications, readmissions, or reoperation rates. Significant postoperative hemoglobin (Hgb) drop (≥3 g/dL) (TA: n = 6, 7.4%, Control: n = 22, 16.6%; p = 0.193) and transfusion rates (intraoperative: TA: n = 2, 2.5%, Control: n = 2, 1.5%; p = 0.586, postoperative: TA: n = 1, 1.2%, Control: 9, 6.8%; p = 0.065) were not statistically different.
Postoperative hemoglobin drop and transfusion rates were not decreased statistically. Further study is warranted given the large clinical differences in favor of TA.
Keywords
Adult, Aged, Antifibrinolytic Agents/therapeutic use, Blood Loss, Surgical/prevention & control, Blood Loss, Surgical/statistics & numerical data, Blood Transfusion/statistics & numerical data, Colectomy, Drug Administration Schedule, Female, Hemostasis, Surgical/methods, Humans, Intraoperative Care/methods, Male, Middle Aged, Patient Safety, Pilot Projects, Proctectomy, Retrospective Studies, Tranexamic Acid/therapeutic use, Treatment Outcome, Colorectal surgery, Patient outcomes, Tranexamic acid
Pubmed
Web of science
Create date
29/11/2021 14:07
Last modification date
30/11/2021 7:09
Usage data