Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Hypertension artérielle pulmonaire primitive et maladie de Basedow [Primary pulmonary hypertension arterial and Basedow disease].
Revue Médicale de la Suisse Romande
Publication types: Case Reports ; English Abstract ; Journal ArticlePublication Status: ppublish
We report a case of a fifty year old woman with Graves' disease with positive AntiTPO antibodies and positive AntiTSH receptor antibodies, who was hospitalized with a right cardiac failure. A pulmonary hypertension was discovered on echocardiography. After adequate antithyroid therapy, the right cardiac failure regressed rapidly and pulmonary pressure normalised. An autoimmune process has often been proposed to explain the association between pulmonary hypertension and hyperthyroidism. We report the arguments supporting this autoimmune etiopathogenesis. We also discuss an other hypothesis based on a direct effect of thyroid hormones on the pulmonary circulation and the effects of high cardiac output associated with hyperthyroidism.
Autoantibodies/analysis, Echocardiography, Female, Graves Disease/complications, Graves Disease/drug therapy, Heart Failure/drug therapy, Heart Failure/immunology, Humans, Hypertension, Pulmonary/drug therapy, Hypertension, Pulmonary/immunology, Middle Aged, Treatment Outcome
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