Clinical manifestations of mucous membrane pemphigoid in a tertiary center.

Details

Serval ID
serval:BIB_43DC645FDD3E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical manifestations of mucous membrane pemphigoid in a tertiary center.
Journal
Klinische Monatsblätter Für Augenheilkunde
Author(s)
Mameletzi E., Hamedani M., Majo F., Guex-Crosier Y.
ISSN
1439-3999 (Electronic)
ISSN-L
0023-2165
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
229
Number
4
Pages
416-419
Language
english
Notes
Publication types: Journal Article
Abstract
Mucous membrane pemphigoid (MMP) is a progressive inflammatory disease of autoimmune etiology. We performed a retrospective analysis of clinical signs and treatment on 16 patients. Conjunctival biopsies were performed in all patients and showed typical immuno-deposits at the basement membrane zone. The mean age at presentation was 69 years, 60 % were female.12 patients demonstrated ocular involvement (11 bilaterally). At the time of referral to our hospital, 92 % had reached an advanced stage III or IV. All patients presented conjunctival fibrosis with resultant fornix foreshortening. Trichiasis and symblepharon were found in 11 patients. Keratitis was found in 11 patients resulting in ulceration in 5 cases. Complications required surgical interventions included: entropion surgery (n = 2), tarsorrhaphy (n = 1), amniotic membrane transplantation (n = 2), keratoplasty (n = 1). Systemic immunomodulatory therapy is the treatment of choice. Dapsone (n = 8), steroids (n = 8), azathioprine (n = 5), cyclophosphamide (n = 2), mycophenolate mofetil (n = 4) and methotrexate (n = 1) were used concomitantly or consecutively. Early diagnosis can prevent ocular complications. Immunomodulatory therapy has provided an avenue for preserving vision. The management of MMP requires a multidisciplinary approach.
Keywords
Adult, Aged, Aged, 80 and over, Conjunctiva/pathology, Female, Humans, Industry, Keratitis/complications, Keratitis/pathology, Male, Middle Aged, Pemphigoid, Benign Mucous Membrane/complications, Pemphigoid, Benign Mucous Membrane/pathology
Pubmed
Web of science
Create date
01/05/2012 10:39
Last modification date
20/08/2019 13:48
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