Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats
Details
Serval ID
serval:BIB_439E5263EDF0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats
Journal
International Journal of Impotence Research
ISSN
0955-9930 (Print)
Publication state
Published
Issued date
12/2003
Volume
15
Number
6
Pages
461-4
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Abstract
The aim of the present study was to test the effects of a topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), on vaginal blood flow and hemodynamics in rats. Laser Doppler flowmetry was used to measure blood flow changes following topical application of DS1 (0.3 or 1.5 mg in 0.15 ml saline) into the vagina of anesthetized Wistar rats. In vivo hemodynamic parameters were measured with Millar-tip-catheter placed in the left ventricle. DS1 (1.5 mg) increased vaginal blood flow by 191+/-24, 226+/-22 and 166+/-23% of the baseline value (at 5, 15 and 30 min, respectively, after application) without affecting systemic blood pressure, heart rate and cardiac function. The increased vaginal blood flow following DS1 application returned to baseline between 45 and 60 min. Thus, topical application of nitric oxide donors such as DS1 may be useful for the treatment of female sexual dysfunction that develops due to an impairment of local blood flow supply to the vaginal tissue.
Keywords
Administration, Topical
Anesthesia
Animals
Female
Nitric Oxide Donors/*pharmacology
Nitroso Compounds/*pharmacology
Polyethyleneimine/*pharmacology
Rats
Rats, Wistar
Regional Blood Flow/*drug effects
Vagina/*blood supply
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 18:00
Last modification date
20/08/2019 14:47