The Human Cortex Possesses a Reconfigurable Dynamic Network Architecture That Is Disrupted in Psychosis.

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Ressource 1Download: Reinen_2018.pdf (4988.05 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_439A1BA08E8E
Type
Article: article from journal or magazin.
Collection
Publications
Title
The Human Cortex Possesses a Reconfigurable Dynamic Network Architecture That Is Disrupted in Psychosis.
Journal
Nature communications
Author(s)
Reinen Jenna M, Chén Oliver Y, Hutchison R. Matthew, Yeo B. T. Thomas, Anderson Kevin M, Sabuncu Mert R, Öngür Dost, Roffman Joshua L, Smoller Jordan W, Baker Justin T, Holmes Avram J
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
20/03/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
1157
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Higher-order cognition emerges through the flexible interactions of large-scale brain networks, an aspect of temporal coordination that may be impaired in psychosis. Here, we map the dynamic functional architecture of the cerebral cortex in healthy young adults, leveraging this atlas of transient network configurations (states), to identify state- and network-specific disruptions in patients with schizophrenia and psychotic bipolar disorder. We demonstrate that dynamic connectivity profiles are reliable within participants, and can act as a fingerprint, identifying specific individuals within a larger group. Patients with psychotic illness exhibit intermittent disruptions within cortical networks previously associated with the disease, and the individual connectivity profiles within specific brain states predict the presence of active psychotic symptoms. Taken together, these results provide evidence for a reconfigurable dynamic architecture in the general population and suggest that prior reports of network disruptions in psychosis may reflect symptom-relevant transient abnormalities, rather than a time-invariant global deficit.
Keywords
Adolescent, Adult, Bipolar Disorder/diagnostic imaging, Bipolar Disorder/physiopathology, Brain Mapping, Cerebral Cortex/diagnostic imaging, Cerebral Cortex/physiopathology, Cognition, Female, Humans, Male, Neural Pathways, Schizophrenia/diagnostic imaging, Schizophrenia/physiopathology, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2024 18:05
Last modification date
18/01/2024 15:12
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