Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis.

Détails

ID Serval
serval:BIB_435BB4B30991
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis.
Périodique
Nature
Auteur(s)
Knobloch M., Braun S.M., Zurkirchen L., von Schoultz C., Zamboni N., Araúzo-Bravo M.J., Kovacs W.J., Karalay O., Suter U., Machado R.A., Roccio M., Lutolf M.P., Semenkovich C.F., Jessberger S.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
10/01/2013
Peer-reviewed
Oui
Volume
493
Numéro
7431
Pages
226-230
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs) have a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPCs and that conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis. The rate of de novo lipid synthesis and subsequent proliferation of NSPCs is regulated by Spot14, a gene previously implicated in lipid metabolism, that we found to be selectively expressed in low proliferating adult NSPCs. Spot14 reduces the availability of malonyl-CoA, which is an essential substrate for Fasn to fuel lipogenesis. Thus, we identify here a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.
Mots-clé
Adult Stem Cells/cytology, Adult Stem Cells/metabolism, Animals, Cell Proliferation, Dentate Gyrus/metabolism, Fatty Acid Synthases/deficiency, Fatty Acid Synthases/genetics, Fatty Acid Synthases/metabolism, Gene Expression Profiling, Hippocampus/cytology, Hippocampus/metabolism, Lipogenesis, Malonyl Coenzyme A/metabolism, Mice, Mice, Transgenic, Neural Stem Cells/cytology, Neural Stem Cells/metabolism, Neurogenesis, Nuclear Proteins/genetics, Nuclear Proteins/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism
Pubmed
Web of science
Création de la notice
25/05/2018 9:31
Dernière modification de la notice
20/08/2019 14:47
Données d'usage