A chemokine-driven positive feedback loop organizes lymphoid follicles

Details

Serval ID
serval:BIB_4351828AC2D7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A chemokine-driven positive feedback loop organizes lymphoid follicles
Journal
Nature
Author(s)
Ansel  K. M., Ngo  V. N., Hyman  P. L., Luther  S. A., Forster  R., Sedgwick  J. D., Browning  J. L., Lipp  M., Cyster  J. G.
ISSN
0028-0836 (Print)
Publication state
Published
Issued date
07/2000
Volume
406
Number
6793
Pages
309-14
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 20
Abstract
Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is required for B-cell migration to splenic follicles, but the requirements for homing to B-cell areas in lymph nodes remain to be defined. Here we show that lymph nodes contain two types of B-cell-rich compartment: follicles containing follicular dendritic cells, and areas lacking such cells. Using gene-targeted mice, we establish that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen. We also find that BLC is required for the development of most lymph nodes and Peyer's patches. In addition to mediating chemoattraction, BLC induces B cells to up-regulate membrane lymphotoxin alpha1beta2, a cytokine that promotes follicular dendritic cell development and BLC expression, establishing a positive feedback loop that is likely to be important in follicle development and homeostasis. In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC.
Keywords
Animals B-Lymphocytes/cytology/*physiology Cell Differentiation Cells, Cultured Chemokines, CXC/genetics/*physiology Dendritic Cells/physiology Feedback Female Lymph Nodes/anatomy & histology/cytology/growth & development/*physiology Lymphotoxin-alpha/biosynthesis Male Mice Peyer's Patches/growth & development Receptors, Chemokine Receptors, Cytokine/genetics/*physiology
Pubmed
Web of science
Create date
24/01/2008 16:04
Last modification date
20/08/2019 14:47
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