Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery

Détails

ID Serval
serval:BIB_4322F5F486A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery
Périodique
American Journal of Obstetrics and Gynecology
Auteur(s)
Genc  M. R., Gerber  S., Nesin  M., Witkin  S. S.
ISSN
0002-9378 (Print)
Statut éditorial
Publié
Date de publication
07/2002
Volume
187
Numéro
1
Pages
157-63
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Résumé
OBJECTIVE: We examined the association between preterm delivery and polymorphisms at position +3953 of the interleukin-1 beta gene (IL1B+3953) and in intron 2 of the interleukin-1 receptor antagonist gene (IL1RN). STUDY DESIGN: This was a case-control study that involved 52 pregnancies that resulted in spontaneous preterm delivery before 34 weeks of gestation and 197 pregnancies that resulted in birth at term. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: Homozygous carriage of IL1B+3953 allele 1 by fetuses of African descent was associated with a risk of preterm delivery (P =.033). Fetuses of Hispanic descent that carried IL1RN allele 2 were found to be at an increased risk for preterm premature rupture of membranes and subsequent preterm delivery(P =.021; odds ratio, 6.5; 95% CI, 1.25-37.7). CONCLUSION: There are associations of spontaneous preterm delivery with the fetal carriage of IL1B+3953*1 and IL1RN*2 alleles in African and Hispanic populations, respectively.
Mots-clé
Adult African Continental Ancestry Group/genetics Case-Control Studies Chromosomes, Human, Pair 2 Female Fetal Membranes, Premature Rupture/ethnology/*genetics Heterozygote Hispanic Americans/genetics Homozygote Humans Interleukin-1/*genetics Obstetric Labor, Premature/ethnology/*genetics Polymerase Chain Reaction *Polymorphism, Genetic Pregnancy Receptors, Interleukin-1/*antagonists & inhibitors
Pubmed
Web of science
Création de la notice
25/01/2008 16:45
Dernière modification de la notice
03/03/2018 16:40
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